Genetic stability of tumor microenvironment
نویسندگان
چکیده
منابع مشابه
Genetic instability induced by the tumor microenvironment.
The tumor microenvironment is characterized by regions of fluctuating hypoxia, low pH, and nutrient deprivation. To determine the genetic consequences of growth under these conditions, we used a tumorigenic cell line carrying a recoverable, chromosomally based lambda phage shuttle vector designed to report mutations without the need for genetic selection of mutant cells. The cells were grown in...
متن کاملGenomic (in)stability of the breast tumor microenvironment.
The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is characterized by genomic instability or whether detection of chromosomal alterations reflects technological artifact rather than the true genomic content of the tumor microenvironment. Th...
متن کاملAngiogenesis, Metastasis, and the Cellular Microenvironment Genomic (In)stability of the Breast Tumor Microenvironment
The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is characterized by genomic instability or whether detection of chromosomal alterations reflects technological artifact rather than the true genomic content of the tumor microenvironment. Th...
متن کاملGenetic Contributions of the Tumor Microenvironment in Breast Cancer Metastasis
Metastasis is a multistage process involving many complex genetic events which facilitate the spread and growth of cancer cells at a secondary site. In vivo models of metastasis are invaluable to our understanding of the interactions between cancer cells and a variety of cell types at the metastatic microenvironment. The objective of this study is to first understand how different in vivo model...
متن کاملTumor Microenvironment
Abstract While genetic changes are critical for the malignant transformation of epithelial cells, the microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise within a cellular microenvironment characterized by suppressed host immunity, dysregulated inflammation, and increased production of cellular growth and survival factors that induce angiogenesis and inhibi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2008
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.7.3.5761